Also Known As
TnI and TnT
Formal Name
Cardiac-specific Troponins I and T (cTnI and cTnT); High-sensitivity cardiac-specific Troponins I and T (hs-cTnI and hs-cTnT)
This article was last reviewed on
This article waslast modified on 18 March 2019.
At a Glance
Why Get Tested?

To see if you have had a heart attack or damage to your heart muscle

When To Get Tested?

If you are having chest pain that may be due to a heart attack.

Sample Required?

A blood sample taken from a vein in the arm

Test Preparation Needed?


On average it takes 7 working days for the blood test results to come back from the hospital, depending on the exact tests requested. Some specialist test results may take longer, if samples have to be sent to a reference (specialist) laboratory. The X-ray & scan results may take longer. If you are registered to use the online services of your local practice, you may be able to access your results online. Your GP practice will be able to provide specific details.

If the doctor wants to see you about the result(s), you will be offered an appointment. If you are concerned about your test results, you will need to arrange an appointment with your doctor so that all relevant information including age, ethnicity, health history, signs and symptoms, laboratory and other procedures (radiology, endoscopy, etc.), can be considered.

Lab Tests Online-UK is an educational website designed to provide patients and carers with information on laboratory tests used in medical care. We are not a laboratory and are unable to comment on an individual's health and treatment.

Reference ranges are dependent on many factors, including patient age, sex, sample population, and test method, and numeric test results can have different meanings in different laboratories.

For these reasons, you will not find reference ranges for the majority of tests described on this web site. The lab report containing your test results should include the relevant reference range for your test(s). Please consult your doctor or the laboratory that performed the test(s) to obtain the reference range if you do not have the lab report.

For more information on reference ranges, please read Reference Ranges and What They Mean.

What is being tested?

Troponins are proteins in muscle fibres that help to regulate muscle contraction. There are three different troponins: skeletal muscle troponin C (TnC) and two heart muscle troponins, cardiac troponin T (cTnT) and cardiac troponin I (cTnI). When there is damage to heart muscle, cTnI and cTnT are released into the blood.

How is the sample collected for testing?

A blood sample is taken by needle from a vein in the arm.

Is any test preparation needed to ensure the quality of the sample?

No test preparation is required.

Accordion Title
Common Questions
  • How is it used?

    Troponin tests are used, together with an electrocardiogram (ECG), in people with persistent chest pain taken to hospital as an emergency to see if they have had a heart attack. In a heart attack a blood clot stops the normal flow of blood and oxygen to the muscle. Without oxygen the heart muscle cells die and release troponin into the bloodstream. The more extensive the damage is, the greater the release and the higher the blood concentrations become. Concentrations can increase within two or three hours and may remain high for 10 to 14 days.

    Until recently a standard cTnI or cTnT troponin blood test would have been used by the laboratory, but these two tests have now mostly been replaced by more sensitive tests producing results called high-sensitivity troponins, hs-cTnI or hs-cTnT. The benefit of the high-sensitivity troponin tests is that they can detect the highly specific marker of heart damage at very low levels which means that early and minor heart damage can be picked up much earlier than the previously used standard troponin tests.

  • When is it requested?

    The biochemical diagnosis of acute heart muscle damage requires an increase in the troponin concentration with time. If a high-sensitivity cardiac troponin (hs-cTn) test is used, a second specimen is taken in three hours or so after admission. Each laboratory purchases and uses different tests (depending on the manufacturer of the equipment used within the laboratory) which may mean that the timing of the blood samples and the values used to interpret the test will vary between hospitals. It is important that results are interpreted alongside local guidelines.

  • What does the test result mean?

    Even a small rise in high-sensitivity (hs-cTn) troponin may indicate some damage to the heart. When a patient has a large increase in troponin concentration, then it is highly likely that they have had a heart attack or some other form of heart damage. If a patient with chest pain and known stable angina has a normal and stable hs-cTn troponin result, it is likely that their heart has not been damaged.

    Increased troponin concentrations should not be used by themselves to diagnose or rule out a heart attack. A physical examination, clinical history and electrocardiogram (ECG) or imaging investigations are also essential. The internationally agreed definition of heart attack requires evidence of a significant increase in troponin concentration with time together with evidence of a sudden reduction of heart muscle blood supply (ischaemia) from characteristic symptoms of the acute coronary syndrome (ACS) and new ECG changes or new imaging changes.

    Without evidence of ischaemia, possible causes of rising troponin values include other causes of heart damage such as myocarditis (inflammation of the heart muscle), acute heart failure, an arrhythmia (abnormal heart rhythm), chest injury, stroke or pulmonary embolism (blood clot lodged in the lung). Elevated but unchanging values may be seen in chronic heart failure, high blood pressure (hypertension), severe infections, kidney disease and some chronic inflammatory conditions of muscle.

  • Is there anything else I should know?

    The test is not generally affected by damage to muscles other than the heart, so injections into muscle and accidents or drugs that damage muscle do not normally affect troponin concentrations.

  • What does heart attack mean?

    Heart attack means that some of the muscle in your heart has died. The medical term for this is myocardial infarction. Most commonly, a heart attack starts with a feeling of heavy pressure or pain in the chest, often extending into the neck or left arm. You may have trouble breathing, and may feel weak and break into a cold sweat.

    A heart attack usually occurs because one of the blood vessels (called coronary arteries) that carry blood to your heart muscle is blocked. This happens when a blood clot forms in a blood vessel that is already partially blocked. The partial blockage is usually due to atherosclerosis (often called hardening of the arteries). This partial blockage occurs gradually over many years as lipid plaques (cholesterol)are deposited along the walls of the blood vessels. These plaques narrow and stiffen the arteries and can break apart unexpectedly and then totally block the affected artery.

  • If I have chest pain, does that mean I am having a heart attack?

    Many other problems can cause chest pain, and it is not always possible to tell from the type of chest pain whether or not you are having a heart attack. Many people have chest pain from straining the muscles in their chest, from heartburn or other problems involving the stomach and the tube which carries food into the stomach (oesophagus), from emotional stress and with some lung problems. Chest pain can be a warning sign of hardening of the arteries of the heart often called coronary artery disease (CAD). Chest pain that occurs during exercise, hard work, or at times of stress, lasts for a few minutes and goes away with rest is called angina. If the pain lasts longer than just a few minutes, especially if it occurs when you are resting, seek immediate medical attention.

  • What if I'm not sure I'm having a heart attack?

    If you have prolonged chest pain, especially if it does not go away with rest or if you have been told you have angina, and the drugs you were prescribed do not ease the pain, seek immediate medical attention.