CK-MB Test
Note: this site is for informational purposes only. To view test results or book a test, use the NHS app in England or contact your GP.
A CK-MB test measures the level of CK-MB, a form of the creatine kinase enzyme, in a blood sample. It is used to help detect and assess damage to the heart muscle, particularly following a heart attack, although it has largely been replaced by troponin testing in many settings.
Why get tested?
This test is not in routine use, it was historically used to help diagnose a a heart attack but since been replaced by the superior marker troponin.
When to get tested?
No longer in routine clinical use.
Sample required?
A blood sample taken from a vein in the arm.
Test preparation needed?
None
Common questions
CK-MB was once the primary test requested for people who had persistent chest pain to see if the pain was coming from the heart. It has now been replaced by the troponin test, which is more specific and sensitive.
It is no longer in routine use within the UK. It may rarely be requested if a total CK concentration is raised but no clear source is identified.
Increased CK-MB concentrations can usually be detected in someone with a heart attack about 4–6 hours after the onset of chest pain. The level of CK-MB peaks approximately at 12–24 hours after the onset of chest pain and then returns to normal within about 48–72 hours.
CK-MB levels may be increased by extensive trauma to skeletal muscles.