Total Protein Test
Note: this site is for informational purposes only. To view test results or book a test, use the NHS app in England or contact your GP.
A total protein test measures the total amount of protein in the blood using a blood sample taken from a vein in the arm. It is used to help assess overall health and to investigate conditions such as liver disease, kidney disease or malnutrition that can affect protein levels.
Why get tested?
Mostly forms a part of a liver function test profile, and not often requested in isolation. It can be used to calculate globulin which may indicate activation or depletion of immune system (immunoglobulin). Can help indicate certain liver, kidney disorders and several other diseases.
When to get tested?
Rarely required alone. Forms part of other test profiles such as liver function tests.
Sample required?
A blood taken from a vein
Test preparation needed?
None
Common questions
An abnormal total protein concentration may indicate a problem in one or both of the main types of proteins. Further tests may be done to find which particular protein is abnormal, so that a diagnosis can be made.
Total protein is usually measured along with several other tests when the liver is being tested.
Low total protein levels can suggest a liver disorder, a kidney disorder, or a disorder in which protein is not digested or absorbed properly or immunoglobulin not being made (for example in bone marrow failure). More specific tests, such as albumin and liver enzyme blood tests, must be performed to make an accurate diagnosis. High total protein levels can indicate dehydration or some types of cancer, that lead to an accumulation of an abnormal protein (such as immunoglobulin in multiple myeloma).
Prolonged application of a tourniquet during blood collection can increase total protein levels. Drugs that may increase protein levels include anabolic steroids, androgens, growth hormone, insulin, and progesterone. Drugs that may decrease protein levels include oestrogens.
No, there is no home test available and it is unlikely to be of any value without a range of other tests being performed and the results interpreted together.