1. Women referred for assisted conception procedures:
A low blood AMH concentration suggests a low follicle count or ovarian reserve and that the woman may respond less well to ovarian stimulation, and an alternative protocol may be followed.
A high blood AMH concentration suggests that the woman has an adequate follicle count or ovarian reserve but may be more likely to have an excessive response to ovarian stimulation and an alternative protocol may be followed.
In no situation does AMH concentration reflect oocyte health or chances for conception.
2. Investigation of abnormal sexual development:
Levels of AMH are much higher in baby boys than in baby girls. Therefore, in an infant with genitals that are not clearly male or female (ambiguous genitalia), the blood AMH concentration can be compared to expected concentrations to help determine the sex of the infant.
In a male child with undescended testicles, a low blood AMH concentration suggests that the testicles have not developed properly. However, a blood AMH concentration that falls within the expected range, alongside evidence from other investigations, indicates that the testicles are present and functional but not located in the usual position.
3. AMH –producing tumours
Some specific ovarian cancers, commonly Granulosa cell tumours may produce AMH, and the concentration of AMH in the blood may then be used to help monitor response to treatment and to look for recurrence.
AMH is not detectable in all ovarian cancers.
4. Other uses of AMH
Low levels of AMH may be related to POI. High levels of the hormone may be due to PCOS. However, measuring AMH levels alone isn’t sufficient to make a clear diagnosis for POI or PCOS.