Erythrocyte Sedimentation Rate (ESR)

The ESR is an easy, inexpensive, non-specific test that has been used for many years to help diagnose conditions associated with acute and chronic (that is, short or long duration) inflammation, including infections, cancers, and autoimmune diseases. ESR is said to be non-specific because increases do not tell the doctor exactly where the inflammation is in your body or what is causing it, and also because it can be affected by other conditions besides inflammation. For this reason, an ESR is typically used in conjunction with other tests – see below ​‘What other tests might my doctor be requesting besides ESR?’.

The ESR is helpful in diagnosing two specific inflammatory diseases, temporal arteritis and polymyalgia rheumatica. A high ESR is one of the main test results used to confirm the diagnosis. It is also used to monitor disease activity and response to therapy in both of these diseases.

An important use of the ESR blood test is to monitor the activity of the underlying condition causing the inflammation and the subsequent response to treatment.

A doctor usually requests an ESR test (along with others – see below ​‘What other tests might my doctor be requesting besides ESR?’) to evaluate a patient who has symptoms that suggest polymyalgia rheumatica or temporal arteritis, such as headaches, neck or shoulder pain, pelvic pain, anaemia, unexplained weight loss, and joint stiffness. There are many other conditions that can result in a temporary or sustained elevation in the ESR and some that will cause a decrease.

Since the ESR is a non-specific marker of inflammation and is affected by other factors, the results must be used along with the doctor’s other clinical findings, the patient’s health history, and results from other appropriate laboratory tests. If the ESR and clinical findings match, the doctor may be able to confirm or rule out a suspected diagnosis. A single elevated ESR, without any symptoms of a specific disease, will usually not give the doctor enough information to make a medical decision.

Before doing an extensive investigation looking for disease, a doctor may want to repeat the ESR test after a period of several weeks or months. If a doctor already knows the patient has a disease like temporal arteritis (where changes in the ESR mirror those in the disease process), they may use the ESR at regular intervals to assist in monitoring the course of the disease. In the case of Hodgkin’s disease, for example, a sustained elevation in ESR may be a predictor of an early relapse following chemotherapy.

Doctors do not base their decisions solely on ESR results. You can have a normal result and still have a problem.

A very high ESR usually has an obvious cause, such as an infection. The doctor will use other follow-up tests, such as cultures, depending on the patient’s symptoms.

Moderately elevated ESR occurs with inflammation, but also with anaemia, infection, pregnancy, and old age.

A rising ESR can mean an increase in inflammation or a poor response to a therapy; a decreasing ESR can mean a good response.

A common cause of high ESR is anaemia, especially if it is associated with changes in the shape of the red cells; however, some changes in red cell shape (such as sickle cells in sickle cell anaemia) lower ESR. Kidney failure will also increase ESR. People with multiple myeloma or Waldenstrom’s macroglobulinaemia (tumours that make large amounts of immunoglobulins) typically have very high ESR even if they don’t have inflammation.

Although a low ESR is not usually important, it can be seen with polycythaemia (a condition where a patient makes too many red blood cells), with extreme leucocytosis (patient has too many white blood cells), and with some protein abnormalities.

The ESR and C‑reactive protein (CRP) are both markers of inflammation. Generally, ESR does not change as rapidly as the concentration of CRP, either at the start of inflammation or as it goes away. CRP is not affected by as many other factors as is ESR, making it a better marker of some types of inflammation. However, because ESR is an easily performed test and CRP must be done using sophisticated laboratory equipment, many doctors still use ESR as an initial test when they think a patient has inflammation.

Females tend to have a slightly higher ESR, and menstruation and pregnancy can cause temporary elevations.

Drugs such as dextran, methyldopa (Aldomet), oral contraceptives, penicillamine procainamide, theophylline, and vitamin A can increase ESR, while aspirin, steroids, and quinine may decrease it.

Your doctor may request a CRP test as well as other biochemistry tests, and an FBC, at the same time they order an ESR. They may also request additional tests based on your symptoms, such as the ANA (antinuclear antibody) and RF (rheumatoid factor) tests suggestive of autoimmune diseases, or cultures to investigate infection. Serum electrophoresis can look for evidence of diseases such as multiple myeloma and lymphoma.

The ESR is an indicator in your body. Like pain, it is giving you a warning that something is wrong. In most cases, the ESR will decrease over time once the underlying inflammation is addressed. If you have a chronic (longstanding) inflammatory disease, the ESR may fluctuate with the degree of activity your condition.