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Complications arise with sensory and motor nerves primarily because injuries and tissue damage are not noticed. Sores that develop may be slow to heal and can become infected. This can lead to tissue erosion, scarring, and, in some cases, the need for amputation. Decreased muscle control can lead to tripping and falling, causing additional damage.

Autonomic neuropathy can cause organ dysfunction, irregular heart rhythms, breathing difficulties, urinary infections, bowel problems, and sexual dysfunction.

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