eGFR - Calc. Creatinine Clearance

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At a Glance

Why Get Tested?

In the UK, the National Institute for Health and Care Excellence (NICE) guidance (CG182) states: “Whenever a request for serum creatinine measurement is made, clinical laboratories should report an estimate of GFR (eGFR)”

When to Get Tested?

As a practical test to look for evidence of kidney damage. For a more definitive assessment of kidney function or to monitor changes in kidney function if you already have kidney disease, measurement of creatinine clearance is preferred.

Sample Required?

eGFR is an estimate of actual glomerular filtration rate, calculated using your age, weight, gender, and serum creatinine (requires a blood sample from a vein in your arm); in some formulas, race is also used in the calculation. Measured Creatinine Clearance, which gives an assessment of Glomerular Filtration Rate (GFR), is calculated from serum and urine creatinine levels and requires a blood sample from a vein in your arm and normally a 24-hour collection of urine. Calculated creatinine clearance is an estimate of creatinine clearance based on the serum creatinine value only and used when it is either not practical or possible to collect a 24 hr urine

Test Preparation Needed?

NICE guidelines advise people not to eat any meat in the 12 hours before having a blood test for eGFR creatinine.